Code : |
4GQB
PDBj
RCSB PDB
PDBe
|
Title : |
Crystal Structure of the human PRMT5:MEP50 Complex |
Release Data : |
2012-10-17 |
Compound : |
mol_id |
molecule |
chains |
synonym
|
1 |
Protein arginine N-methyltransferase 5
|
A
|
72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs, Protein arginine N-methyltransferase 5, N-terminally processed
|
|
ec: 2.1.1.-, 2.1.1.125
|
mol_id |
molecule |
chains |
synonym
|
2 |
Methylosome protein 50
|
B
|
MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50
|
mol_id |
molecule |
chains |
|
3 |
Histone H4 peptide
|
C
|
|
|
Source : |
mol_id |
organism_scientific |
organism_common
|
expression_system
|
1 |
Homo sapiens
(taxid:9606)
|
Human
|
Spodoptera frugiperda
(taxid:7108)
|
|
gene: PRMT5, HRMT1L5, IBP72, JBP1, SKB1
|
mol_id |
organism_scientific |
organism_common
|
expression_system
|
2 |
Homo sapiens
(taxid:9606)
|
Human
|
Spodoptera frugiperda
(taxid:7108)
|
|
gene: WDR77, MEP50, HKMT1069, Nbla10071
|
mol_id |
organism_scientific |
organism_common
|
|
3 |
Homo sapiens
(taxid:9606)
|
Human
|
|
|
synthetic: yes
|
|
Authors : |
Antonysamy, S., Bonday, Z., Campbell, R., Doyle, B., Druzina, Z., Gheyi, T., Han, B., Jungheim, L.N., Qian, Y., Rauch, C., Russell, M., Sauder, J.M., Wasserman, S.R., Weichert, K., Willard, F.S., Zhang, A., Emtage, S. |
Keywords : |
TIM BARREL, BETA-PROPELLER, METHYLTRANSFERASE, METHYLATION, TRANSFERASE-PROTEIN BINDING complex |
Exp. method : |
X-RAY DIFFRACTION ( 2.06 Å ) |
Citation : |
Crystal structure of the human PRMT5:MEP50 complex.
Antonysamy, S.,Bonday, Z.,Campbell, R.M.
et al.
(2012)
Proc.Natl.Acad.Sci.USA
109
: 17960
- 17965
PubMed: 23071334
DOI: 10.1073/pnas.1209814109
|