Brand  (β version)

color scheme of protein:

chain: Hide other chain(s)

Modified Residues
Code Name Link
0XL 2-amino-2-ethylbutanoic acid
0XM 1,1-diphenylmethanamine
AC5 1-aminocyclopentanecarboxylic acid
ALQ 2-methyl-propionic acid
Code : 4GM3
Header : TRANSCRIPTION/TRANSCRIPTION INHIBITOR
Title : Crystal structure of human WD repeat domain 5 with compound MM-101
Release Data : 2013-07-31
Compound :
mol_id molecule chains synonym
1 WD repeat-containing protein 5 A,B,C,D,E,F,G,H WDR5, BMP2-induced 3-kb gene protein
fragment: UNP residues 22-334
mol_id molecule chains
2 MM-101 I,J,K,L,M,N,O,P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: WDR5, BIG3
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: PET28b-sumo
mol_id organism_scientific
2
synthetic: yes
Authors : Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
Keywords : MLL1, histone methyltransferase, WD40, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.393 Å )
Citation :

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.

Karatas, H.,Townsend, E.C.,Cao, F.  et al.
(2013)  J.Am.Chem.Soc.  135 : 669 - 682

PubMed: 23210835
DOI: 10.1021/ja306028q

Chain : A, B, C, D, E, F, G, H
UniProt : P61964 (WDR5_HUMAN)
Reaction : -