Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
ZN Zinc ion
0O1 6-amino-4-{2-[(cyclopentylmethyl)amino]ethyl}-2-[(2-phenylethyl)amino]-3,7-dihydro-8h-imidazo[4,5-G]quinazolin-8-one
GOL Glycerol
Code : 4GKT
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor
Release Data : 2013-09-04
Compound :
mol_id molecule chains synonym
1 Queuine tRNA-ribosyltransferase A Guanine insertion enzyme, tRNA-guanine transglycosylase
ec: 2.4.2.29
mutation: T312K
Source :
mol_id organism_scientific expression_system
1 Zymomonas mobilis subsp. mobilis  (taxid:264203) Escherichia coli  (taxid:469008)
strain: ATCC 31821 / ZM4 / CP4
gene: tgt, ZMO0363
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET9D
Authors : Immekus, F., Klebe, G.
Keywords : TIM BARREL, GLYCOSYLTRANSFERASE, QUEUOSINE, BIOSYNTHESIS, TRNA PROCESSING, TRNA, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.53 Å )
Citation :

Two-armed benzopurine inhibitors of TGT

Immekus, F.,Barandun, L.J.,Diederich, F.  et al.
To be Published 

Chain : A
UniProt : P28720 (TGT_ZYMMO)
Reaction : Guanine(34) in tRNA + 7-aminomethyl-7- carbaguanine = 7-aminomethyl-7-carbaguanine(34) in tRNA + guanine.