PDB ID: 4GJD
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0N0 | (3s,5r)-N-{[9-(4-methoxybutyl)-9h-xanthen-9-yl]methyl}-5-{[(4-methylphenyl)sulfonyl]amino}piperidine-3-carboxamide | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM |
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NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose |
Code | Name | Show |
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Download interaction data: 4GJD
Structure summary
Code : | 4GJD PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal structure of renin in complex with NVP-BGQ311 (compound 12) | ||||||||||||
Release Data : | 2013-02-13 | ||||||||||||
Compound : |
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Authors : | Ostermann, N., Zink, F., Kroemer, M. | ||||||||||||
Keywords : | renin inhibitor, fragment based screening, 3, 5-disubstituted piperidines, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.65 Å ) | ||||||||||||
Citation : |
A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
Ostermann, N.,Ruedisser, S.,Ehrhardt, C.
et al.
PubMed: 23360239 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P00797 (RENI_HUMAN) | ||||||||
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