PDB ID: 4GJB
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Structure summary
Code : | 4GJB PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal structure of renin in complex with NVP-BBV031 (compound 6) | ||||||||||||
Release Data : | 2013-02-13 | ||||||||||||
Compound : |
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Authors : | Ostermann, N., Zink, F., Kroemer, M. | ||||||||||||
Keywords : | renin inhibitor, fragment based screening, 3, 5-disubstituted piperidines, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.75 Å ) | ||||||||||||
Citation : |
A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
Ostermann, N.,Ruedisser, S.,Ehrhardt, C.
et al.
PubMed: 23360239 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P00797 (RENI_HUMAN) | ||||||||
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