Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0XH 2,6-dichloro-N-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
Code : 4GJ2
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
Release Data : 2013-05-29
Compound :
mol_id molecule chains
1 Non-receptor tyrosine-protein kinase TYK2 A
ec: 2.7.10.2
fragment: Kinase domain, UNP residues 696-1022
mutation: C936A,Q969A,E971A,K972A,D1023N,C1142A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: Tyk2 gene
expression_system_common: Fall armyworm
Authors : Ultsch, M.H.
Keywords : Kinase, ATP Binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.

Liang, J.,van Abbema, A.,Balazs, M.  et al.
(2013)  J.Med.Chem.  56 : 4521 - 4536

PubMed: 23668484
DOI: 10.1021/jm400266t

Chain : A
UniProt : P29597 (TYK2_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.