Brand  (β version)

PDB ID: 4GIZ

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
GLC Alpha-D-glucopyranose PoSSuM
: Polysaccharide
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Structure summary

Code : 4GIZ   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution
Release Data : 2013-01-23
Compound :
mol_id molecule chains synonym
1 Maltose-binding periplasmic protein, UBIQUITIN LIGASE EA6P: chimeric protein A,B MBP, MMBP, Maltodextrin-binding protein
fragment: unp residues 27-392/403-414
mutation: D83A,K84A,K240A,E360A,D364A,K363A
mol_id molecule chains
2 Protein E6 C,D
fragment: unp residues 9-150
mutation: F47R,C80S,C97S,C111S,C140S
Source :
mol_id organism_scientific expression_system
1 HOMO SAPIENS  (taxid:9606) Escherichia coli  (taxid:562)
strain: K12
gene: malE, b4034, JW3994
mol_id organism_scientific expression_system
2 Human papillomavirus type 16  (taxid:333760) Escherichia coli  (taxid:562)
gene: E6
Authors : McEwen, A.G., Zanier, K., Charbonnier, S., Poussin, P., Cura, V., Vande Pol, S., Trave, G., Cavarelli, J.
Keywords : VIRAL PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.55 Å )
Citation :

Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

Zanier, K.,Charbonnier, S.,Sidi, A.O.  et al.
(2013)  Science  339 : 694 - 698

PubMed: 23393263
DOI: 10.1126/science.1229934

Reaction

Chain : A, B
UniProt : P0AEX9 (MALE_ECOLI)
Reaction : -
Chain : A, B
UniProt : Q05086 (UBE3A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.26 PubMed:24273172
-
Chain : C, D
UniProt : P03126 (VE6_HPV16)
Reaction : -