Het-PDB Navi2 (PDB: 4GII)

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Ligands
Code	Name		Style	Show	Link
0X6	2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4GII

Code :

4GII PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide

Release Data :

2013-05-29

Compound :

mol_id	molecule	chains
1	Non-receptor tyrosine-protein kinase TYK2	A
	ec: 2.7.10.2 fragment: Kinase domain, UNP residues 885-1176 mutation: C936A,Q969A,E971A,K972A,D1023N,C1142A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: TYK2 expression_system_common: Fall armyworm

Authors :

Ultsch, M.H.

Keywords :

Aminopyridine, Benzamide, Kinase, Enzyme inhibitor, Tyrosine Kinase, ATP Binding, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.31 Å )

Citation :

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.

Liang, J.,van Abbema, A.,Balazs, M. et al.
(2013) J.Med.Chem. 56 : 4521 - 4536

Chain :

UniProt :

P29597 (TYK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PubMed:10542297, PubMed:7526154
	-	PubMed:10542297, PubMed:7526154

PDB ID: 4GII