Het-PDB Navi2 (PDB: 4GI4)

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Ligands
Code	Name		Style	Show	Link
0EX	6-amino-4-[2-(benzylamino)ethyl]-2-[(2-phenylethyl)amino]-1,7-dihydro-8h-imidazo[4,5-G]quinazolin-8-one				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4GI4

Code :

4GI4 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE inhibitor

Title :

tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor

Release Data :

2013-09-04

Compound :

mol_id	molecule	chains	synonym
1	Queuine tRNA-ribosyltransferase	A	Guanine insertion enzyme, tRNA-guanine transglycosylase
	ec: 2.4.2.29 mutation: T312K

Source :

mol_id	organism_scientific	expression_system
1	Zymomonas mobilis subsp. mobilis (taxid:264203)	Escherichia coli (taxid:469008)
	strain: ATCC 31821 / ZM4 / CP4 gene: tgt, ZMO0363 expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_plasmid: PET9D

Authors :

Immekus, F., Klebe, G.

Keywords :

TIM BARREL GLYCOSYLTRANSFERASE, QUEUOSINE, BIOSYNTHESIS, TRNA PROCESSING, TRNA, TRANSFERASE-TRANSFERASE inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.97 Å )

Citation :

High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.

Barandun, L.J.,Immekus, F.,Kohler, P.C. et al.
(2013) Acta Crystallogr.,Sect.D 69 : 1798 - 1807

Chain :

UniProt :

P28720 (TGT_ZYMMO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7- aminomethyl-7-carbaguanosine(34) in tRNA + guanine	2.4.2.29	HAMAP-Rule:MF_00168, PubMed:7665516
	-	HAMAP-Rule:MF_00168, PubMed:7665516
Cofactor:	Evidence:	Note:
Zn(2+)	ECO:0000255 \| HAMAP-Rule:MF_00168 ECO:0000269 \| PubMed:10413112 ECO:0000269 \| PubMed:11178905 ECO:0000269 \| PubMed:11921407 ECO:0000269 \| PubMed:12646024 ECO:0000269 \| PubMed:12909636 ECO:0000269 \| PubMed:12949492 ECO:0000269 \| PubMed:14523925 ECO:0000269 \| PubMed:19627989 ECO:0000269 \| PubMed:8654383 ECO:0000269 \| PubMed:8961936	Binds 1 zinc ion per subunit.

PDB ID: 4GI4