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Ligands
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0WX 4-{2-[(cyclohexylmethyl)amino]ethyl}-2-{[2-(morpholin-4-yl)ethyl]amino}-3,7-dihydro-8h-imidazo[4,5-G]quinazolin-8-one
GOL Glycerol
ZN Zinc ion
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Code : 4GH1   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE inhibitor
Title : tRNA Guanine Transglycosylase in complex with morpholine substituted lin-benzohypoxanthine inhibitor
Release Data : 2013-09-04
Compound :
mol_id molecule chains synonym
1 Queuine tRNA-ribosyltransferase A Guanine insertion enzyme, tRNA-guanine transglycosylase
ec: 2.4.2.29
mutation: T312K
Source :
mol_id organism_scientific expression_system
1 Zymomonas mobilis subsp. mobilis  (taxid:264203) Escherichia coli  (taxid:469008)
strain: ATCC 31821 / ZM4 / CP4
gene: tgt, ZMO0363
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET9D
Authors : Immekus, F., Klebe, G.
Keywords : TIM BARREL, GLYCOSYLTRANSFERASE, QUEUOSINE, BIOSYNTHESIS, TRNA PROCESSING, TRNA, TRANSFERASE-TRANSFERASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.45 Å )
Citation :

Two-armed benzopurine inhibitors of TGT

Immekus, F.,Barandun, L.J.,Diederich, F.  et al.
To be Published 

Chain : A
UniProt : P28720 (TGT_ZYMMO)
Reaction: EC: Evidence:
Physiological Direction:
7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7- aminomethyl-7-carbaguanosine(34) in tRNA + guanine 2.4.2.29 HAMAP- Rule:MF_00168, PubMed:7665516
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