Brand  (β version)

PDB ID: 4GFG

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Ligands
Code Name Style Show Link
0XF 6-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(5,6-dimethylpyridin-2-yl)amino]pyridazine-3-carboxamide PoSSuM
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Structure summary

Code : 4GFG   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of spleen tyrosine kinase complexed with r9021
Release Data : 2013-08-14
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase SYK A Spleen tyrosine kinase, p72-Syk
ec: 2.7.10.2
fragment: Kinase domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human SPODOPTERA FRUGIPERDA  (taxid:7108)
gene: SYK
expression_system_cell_line: SF9
Authors : Lukacs, C., Slade, M.
Keywords : SYK, SPLEEN TYPROSINE KINASE, PYRIMIDINE-5-CARBOXAMIDE, ATP-BINDING, HOST-VIRUS INTERACTION, NUCLEOTIDE-BINDING, PHOSPHOPROTEIN, SH2 DOMAIN, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

A specific SYK inhibitor blocks B Cell Receptor, Fc Receptor, and Toll-like Receptor 9 pathways for the treatment of inflammatory diseases.

Hsu, J.,Kim, Y.,Hu, D.-Q.  et al.
To be Published 

Reaction

Chain : A
UniProt : P43405 (KSYK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
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