Het-PDB Navi2 (PDB: 4GFD)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
0YB	2-(3-bromophenoxy)-4-{(1r)-3,3-dimethyl-1-[(3s)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)piperidin-1-yl]butyl}benzoic acid				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4GFD

Code :

4GFD PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Thymidylate kinase (TMK) from S. Aureus in complex with TK-666

Release Data :

2012-10-24

Compound :

mol_id	molecule	chains	synonym
1	Thymidylate kinase	A,B	dTMP kinase
	ec: 2.7.4.9

Source :

mol_id	organism_scientific	expression_system
1	Staphylococcus aureus subsp. aureus (taxid:158879)	Escherichia coli (taxid:562)
	strain: strain Mu50 gene: SA0440, tmk expression_system_strain: BL21 DE3 pLysS expression_system_vector_type: pET30a expression_system_plasmid: pLH1520

Authors :

Olivier, N.B., Martinez-Botella, G., Keating, T.

Keywords :

kinase, thymidine monphosphate, soluble, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.80 Å )

Citation :

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound.

Keating, T.A.,Newman, J.V.,Olivier, N.B. et al.
(2012) Acs Chem.Biol. 7 : 1866 - 1872

Chain :

A, B

UniProt :

P65249 (KTHY_STAAN)

PDB ID: 4GFD