PDB ID: 4GEE
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0WT | (1r,5s,6s)-3-[5-chloro-6-ethyl-2-(pyrimidin-5-yloxy)-7h-pyrrolo[2,3-D]pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-amine | PoSSuM | |||
GOL | Glycerol | PoSSuM |
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Download interaction data: 4GEE
Structure summary
Code : | 4GEE PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Isomerase/Isomerase inhibitor | ||||||||||||
Title : | Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | ||||||||||||
Release Data : | 2013-02-13 | ||||||||||||
Compound : |
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Source : |
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Authors : | Bensen, D.C., Chen, Z., Tari, L.W. | ||||||||||||
Keywords : | ATP-binding, Nucleotide-binding, Topoisomerase, ATP-binding domain, DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, Isomerase-Isomerase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.70 Å ) | ||||||||||||
Citation : |
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Tari, L.W.,Trzoss, M.,Bensen, D.C.
et al.
PubMed: 23352267 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q839Z1 (GYRB_ENTFA) | ||||||||
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