Brand  (β version)

PDB ID: 4G5J

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Ligands
Code Name Style Show Link
0WN N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide PoSSuM
0WM (2e)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide PoSSuM
Non-standard Residues
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Structure summary

Code : 4G5J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of EGFR kinase in complex with BIBW2992
Release Data : 2012-08-29
Compound :
mol_id molecule chains synonym
1 Epidermal growth factor receptor A Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
ec: 2.7.10.1
fragment: Kinase dimain, UNP residues 696-1022
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Solca, F., Dahl, G., Zoephel, A., Bader, G., Sanderson, M., Klein, C., Kraemer, O., Himmelsbach, F., Haaksma, E., Adolf, G.R.
Keywords : PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker.

Solca, F.,Dahl, G.,Zoephel, A.  et al.
(2012)  J.Pharmacol.Exp.Ther.  343 : 342 - 350

PubMed: 22888144
DOI: 10.1124/jpet.112.197756

Reaction

Chain : A
UniProt : P00533 (EGFR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
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