Brand  (β version)

PDB ID: 4G3E

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
0WC (2r)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1h-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4G3E   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)
Release Data : 2012-08-15
Compound :
mol_id molecule chains synonym
1 NF-kappa-beta-inducing kinase A,B Serine/threonine-protein kinase NIK
ec: 2.7.11.25
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Map3k14, NF-kappaB inducing kinase, Nik
expression_system_strain: SF9
expression_system_vector_type: baculovirus transfer vector
expression_system_plasmid: pAcGP67
Authors : Hymowitz, S.G., de Leon-Boenig, G.
Keywords : non-RD kinase, protein serine/threonine kinase, NF-kappaB, Structure-based drug design, MAP3K14, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.

de Leon-Boenig, G.,Bowman, K.K.,Feng, J.A.  et al.
(2012)  Structure  20 : 1704 - 1714

PubMed: 22921830
DOI: 10.1016/j.str.2012.07.013

Reaction

Chain : A, B
UniProt : Q9WUL6 (M3K14_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.25 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.25 -
-