Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0VP 3-(5'-{[3,4-bis(hydroxymethyl)benzyl]oxy}-2'-ethyl-2-propylbiphenyl-4-yl)pentan-3-ol
Code : 4G1Z
Header : transcription/transcription inhibitor
Title : Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor
Release Data : 2012-09-26
Compound :
mol_id molecule chains synonym
1 Vitamin D3 receptor A A VDR-A, 1,25-dihydroxyvitamin D3 receptor A, Nuclear receptor subfamily 1 group I member 1-A
fragment: unp residues 156-453
mol_id molecule chains synonym
2 Nuclear receptor coactivator 1 B NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
ec: 2.3.1.48
fragment: unp residues 686-692
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Leopard danio,zebra danio,zebra fish Escherichia coli  (taxid:562)
gene: vdra, nr1i1a, vdr
expression_system_strain: BL21DE3
expression_system_plasmid: pET28
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
other_details: from human sequence
Authors : Ciesielski, F., Sato, Y., Moras, D., Rochel, N.
Keywords : VDR, nuclear receptor, transcription regulation, alpha helical sandwich, ligand, DNA, phosphorylation, nucleus, transcription-transcription inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.

Ciesielski, F.,Sato, Y.,Chebaro, Y.  et al.
(2012)  J.Med.Chem.  55 : 8440 - 8449

PubMed: 22957834
DOI: 10.1021/jm300858s

Chain : A
UniProt : Q9PTN2 (VDRA_DANRE)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction : Acetyl-CoA + [histone] = CoA + acetyl- [histone].