Brand  (β version)

PDB ID: 4G1C

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CNA Carba-nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
Code Name Show
SLL (2s)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show
ACE Acetyl group
NH2 Amino group

Structure summary

Code : 4G1C   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human SIRT5 bound to Succ-IDH2 and Carba-NAD
Release Data : 2012-08-15
Compound :
mol_id molecule chains synonym
1 NAD-dependent protein deacylase sirtuin-5, mitochondrial A,B Regulatory protein SIR2 homolog 5, SIR2-like protein 5
ec: 3.5.1.-
fragment: UNP residues 36-302
mol_id molecule chains
2 Succinylated IDH2 peptide D,E
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SIRT5, SIR2L5
mol_id organism_scientific
2
synthetic: yes
other_details: Synthetic Succ-IDH2 peptide
Authors : Dai, H.
Keywords : Sirtuin, Succinylated peptide, CarbaNAD, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.944 Å )
Citation :

Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5.

Szczepankiewicz, B.G.,Dai, H.,Koppetsch, K.J.  et al.
(2012)  J.Org.Chem.  77 : 7319 - 7329

PubMed: 22849721
DOI: 10.1021/jo301067e

Reaction

Chain : A, B
UniProt : Q9NXA8 (SIR5_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide - HAMAP-Rule:MF_03160, PubMed:22076378
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H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O- succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - HAMAP-Rule:MF_03160, PubMed:22076378, PubMed:29180469
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H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O- glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide - HAMAP-Rule:MF_03160, PubMed:24703693
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