Brand  (β version)

PDB ID: 4G17

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Ligands
Code Name Style Show Link
0VN 2-[(4-tert-butylphenyl)amino]-1h-benzimidazole-6-carbonitrile PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4G17   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE inhibitor
Title : Crystal structure of ck1g3 with 2-[(4-TERT-BUTYLPHENYL)AMINO]-1H-BENZIMIDAZOLE-6-CARBONITRILE
Release Data : 2013-05-22
Compound :
mol_id molecule chains synonym
1 Casein kinase I isoform gamma-3 A CKI-gamma 3
ec: 2.7.11.1
fragment: unp residues 34-362
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK1G3
Authors : Huang, X.
Keywords : ck1g, kinase, inhibitor, TRANSFERASE-TRANSFERASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1g)inhibitors

Hua, Z.,Huang, X.,Bregman, H.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 5392 - 5395

PubMed: 22877629
DOI: 10.1016/j.bmcl.2012.07.046

Reaction

Chain : A
UniProt : Q9Y6M4 (KC1G3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
-