Het-PDB Navi2 (PDB: 4FYN)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
0VE	3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4FYN

Code :

4FYN PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-phenylamino}-imidazo[1,2-a]pyrazin-5-yl)-phenol

Release Data :

2013-01-30

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase SYK	A	Spleen tyrosine kinase, p72-Syk
	ec: 2.7.10.2 fragment: RESIDUES 356-635, PROTEIN KINASE DOMAIN

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: SYK expression_system_common: Fall armyworm expression_system_strain: SF9 expression_system_vector_type: BACULOVIRUS

Authors :

Kuglstatter, A., Villasenor, A.G.

Keywords :

kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.318 Å )

Citation :

Rational design of highly selective spleen tyrosine kinase inhibitors.

Lucas, M.C.,Goldstein, D.M.,Hermann, J.C. et al.
(2012) J.Med.Chem. 55 : 10414 - 10423

Chain :

UniProt :

P43405 (KSYK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
	-	PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301

PDB ID: 4FYN