PDB ID: 4FOB
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Structure summary
Code : | 4FOB PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Transferase/Inhibitor | ||||||||||||
Title : | Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1 | ||||||||||||
Release Data : | 2012-07-11 | ||||||||||||
Compound : |
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Source : |
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Authors : | Whittington, D.A., Epstein, L.F., Chen, H. | ||||||||||||
Keywords : | receptor tyrosine kinase, inhibitor, crizotinib, neuroblastoma, CD246, phosphotransferase, NPM-ALK, EML4-ALK, in situ proteolysis, Transferase-Inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.9000 Å ) | ||||||||||||
Citation : |
The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer.
Lewis, R.T.,Bode, C.M.,Choquette, D.M.
et al.
PubMed: 22734674 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q9UM73 (ALK_HUMAN) | ||||||||
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