Brand  (β version)

PDB ID: 4FO6

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
F2A 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine PoSSuM
MG Magnesium ion PoSSuM
MN Manganese (II) ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4FO6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE, LYASE/DNA
Title : Crystal structure of the pre-catalytic ternary complex of polymerase lambda with a dATP analog opposite a templating T and an rCMP at the primer terminus.
Release Data : 2012-07-11
Compound :
mol_id molecule chains synonym
1 DNA polymerase lambda A Pol Lambda, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa
ec: 2.7.7.7, 4.2.99.-
fragment: Loop mutant of DNA polymerase lambda
mutation: SQEENGQQQ to KGET
mol_id molecule chains
2 5'-D(*CP*GP*GP*CP*TP*GP*TP*AP*CP*TP*G)-3' T
mol_id molecule chains
3 5'-D(*CP*AP*GP*TP*AP)-R(P*C)-3' P
mol_id molecule chains
4 5'-D(P*GP*CP*CP*G)-3' D
mol_id molecule chains
5 5'-D(P*TP*AP*CP*TP*G)-3' H
mol_id molecule chains
6 5'-D(P*CP*AP*GP*TP*A)-3' I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLL
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3
synthetic: yes
mol_id organism_scientific
4
synthetic: yes
mol_id organism_scientific
5
synthetic: yes
mol_id organism_scientific
6
Authors : Gosavi, R.A., Moon, A.F., Kunkel, T.A., Pedersen, L.C., Bebenek, K.
Keywords : DNA polymerase, TRANSFERASE, LYASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.007 Å )
Citation :

The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda

Gosavi, R.A.,Moon, A.F.,Kunkel, T.A.  et al.
(2012)  Nucleic Acids Res.  40 : 1 - 10

PubMed: 22584622
DOI: 10.1093/nar/gks413

Reaction

Chain : A
UniProt : Q9UGP5 (DPOLL_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195
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