Het-PDB Navi2 (PDB: 4FKI)

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Ligands
Code	Name		Style	Show	Link
09K	N-(5-cyclopropyl-1h-pyrazol-3-yl)-2-[4-(trifluoromethoxy)phenyl]acetamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
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Modification
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ACE	Acetyl group

Download interaction data: 4FKI

Code :

4FKI PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor

Release Data :

2013-05-08

Compound :

mol_id	molecule	chains	synonym
1	Cyclin-dependent kinase 2	A	Cell division protein kinase 2, p33 protein kinase
	ec: 2.7.11.22

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	TRICHOPLUSIA NI (taxid:7111)
	gene: CDK2, CDKN2 expression_system_cell_line: HIGH-FIVE expression_system_vector_type: BACULOVIRUS expression_system_plasmid: PFB1

Authors :

Kang, Y.N., Stuckey, J.A.

Keywords :

ALPHA AND BETA PROTEIN (A+B), TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 1.60 Å )

Citation :

Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor

Kang, Y.N.,Stuckey, J.A.
To be Published

Chain :

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781

PDB ID: 4FKI