Het-PDB Navi2 (PDB: 4FIC)

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Ligands
Code	Name		Style	Show	Link
0UL	6-phenyl[1,2,4]triazolo[1,5-a]pyrazin-2-amine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4FIC

Code :

4FIC PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Kinase domain of cSrc in complex with a hinge region-binding fragment

Release Data :

2013-04-10

Compound :

mol_id	molecule	chains	synonym
1	Proto-oncogene tyrosine-protein kinase Src	A,B	Proto-oncogene c-Src, pp60c-src, p60-Src
	ec: 2.7.10.2 fragment: Kinase Domain of chicken Src (UNP residues 251-533)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Gallus gallus (taxid:9031)	Bantam,chickens	Escherichia coli (taxid:469008)
	gene: SRC, v-Src expression_system_strain: BL21(DE3) expression_system_vector_type: Plasmid expression_system_plasmid: pSKB3

Authors :

Richters, A., Rauh, D.

Keywords :

Hinge binding fragment, Type I, DFG-in, Tyrosine-protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.5000 Å )

Citation :

De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.

Urich, R.,Wishart, G.,Kiczun, M. et al.
(2013) Acs Chem.Biol. 8 : 1044 - 1052

Chain :

A, B

UniProt :

P00523 (SRC_CHICK)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 4FIC