Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0UA 3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 4FI7   PDBj   RCSB PDB   PDBe
Header : HORMONE/HORMONE INHIBITOR
Title : Kinetic Stabilization of transthyretin through covalent modification of K15 by 3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide
Release Data : 2013-02-20
Compound :
mol_id molecule chains synonym
1 Transthyretin A,B ATTR, Prealbumin, TBPA
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: TTR, PALB
expression_system_strain: Epicurian Gold
expression_system_vector_type: Plasmid
expression_system_plasmid: PMMHA
Authors : Connelly, S., Grimster, N., Wilson, I.A., Kelly, J.W.
Keywords : hormone, binding protein, Covalent kinetic stabilizer, HORMONE-HORMONE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.4020 Å )
Citation :

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.

Grimster, N.P.,Connelly, S.,Baranczak, A.  et al.
(2013)  J.Am.Chem.Soc.  135 : 5656 - 5668

PubMed: 23350654
DOI: 10.1021/ja311729d

Chain : A, B
UniProt : P02766 (TTHY_HUMAN)
Reaction : -