Brand  (β version)

PDB ID: 4FH2

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Ligands
Code Name Style Show Link
0RN Sulbactam PoSSuM
MA4 Cyclohexyl-hexyl-beta-D-maltoside PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4FH2   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Structure of s70c beta-lactamase bound to sulbactam
Release Data : 2012-09-26
Compound :
mol_id molecule chains synonym
1 Beta-lactamase SHV-1 A PIT-2
ec: 3.5.2.6
fragment: unp residues 22-286
mutation: S70C
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:562)
gene: bla, shv1
Authors : Rodkey, E.A., van den Akker, F.
Keywords : class A beta-lactamase, hydrolase, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.44 Å )
Citation :

Crystal structure of a pre-acylation complex of the beta-lactamase inhibitor, sulbactam, bound to a sulfenamide bond containing thiol-beta-lactamase

Rodkey, E.A.,Drawz, S.M.,Sampson, J.M.  et al.
(2012)  J.Am.Chem.Soc.  134 : 16798 - 16804

PubMed: 22974281
DOI: 10.1021/ja3073676

Reaction

Chain : A
UniProt : P0AD64 (BLA1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE-ProRule:PRU10101, PubMed:10231522, PubMed:19351161, PubMed:22908166, PubMed:23252553
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