PDB ID: 4FGK
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Code | Name | Style | Show | Link | |
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0TX | (4s)-N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine | PoSSuM | |||
FAD | Flavin-adenine dinucleotide | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
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Download interaction data: 4FGK
Structure summary
Code : | 4FGK PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor | ||||||||||||
Title : | Oxidized quinone reductase 2 in complex with chloroquine | ||||||||||||
Release Data : | 2013-03-13 | ||||||||||||
Compound : |
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Source : |
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Authors : | Leung, K.K., Shilton, B.H. | ||||||||||||
Keywords : | chloroquine, FMN reductase superfamily (conserved domain database), metallo-flavoprotein, Rossmann fold, two-electron reduction of quinones to hydroquinones, FAD binding, Zn binding, cytosol, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.4010 Å ) | ||||||||||||
Citation : |
Crystal structures of quinone reductase 2 bound to antimalarial drugs reveal conformational change upon reduction
Leung, K.K.,Shilton, B.H.
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Reaction
Chain : | A, B | ||||||||
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UniProt : | P16083 (NQO2_HUMAN) | ||||||||
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