Brand  (β version)

PDB ID: 4FF6

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
0T4 3-(hydroxyamino)-N-[(1r)-1-phenylethyl]-5-(trifluoromethyl)benzamide PoSSuM
IMD Imidazole PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4FF6   PDBj   RCSB PDB   PDBe
Header : oxidoreductase/oxidoreductase inhibitor
Title : Mycobacterium tuberculosis DprE1 in complex with CT325 - monoclinic crystal form
Release Data : 2012-07-04
Compound :
mol_id molecule chains
1 Probable decaprenylphosphoryl-beta-D-ribose oxidase A,B
ec: 1.-.-.-
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
strain: H37Rv
gene: dprE1, MT3898, Rv3790
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Batt, S.M., Besra, G.S., Futterer, K.
Keywords : alpha+beta, oxidoreductase, decaprenylphosphoryl-beta-D-ribose, oxidoreductase-oxidoreductase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.600 Å )
Citation :

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.

Batt, S.M.,Jabeen, T.,Bhowruth, V.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : 11354 - 11359

PubMed: 22733761
DOI: 10.1073/pnas.1205735109

Reaction

Chain : A, B
UniProt : P72056 (multiple entry names are found)
Reaction : -