Het-PDB Navi2 (PDB: 4FEQ)

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Ligands
Code	Name		Style	Show	Link
0T8	4-(cyclopentylamino)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamide				PoSSuM

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Download interaction data: 4FEQ

Code :

4FEQ PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase TYRO3 (Sky)

Release Data :

2013-03-13

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase receptor TYRO3	A	Etk2/tyro3, TK19-2, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE
	ec: 2.7.10.1 fragment: Kinase domain (UNP residues 485-800)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Spodoptera frugiperda (taxid:7108)
	gene: Tyro3, Dtk, Rse expression_system_common: Fall armyworm

Authors :

Ohren, J.F., Powell, N.A., Kohrt, J.T., Perrin, L.A.

Keywords :

Protein kinase domain, Receptor Tyrosine Kinase, Gas6, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Powell, N.A.,Hoffman, J.K.,Ciske, F.L. et al.
(2013) Bioorg.Med.Chem.Lett. 23 : 1046 - 1050

Chain :

UniProt :

P55144 (TYRO3_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 4FEQ