Het-PDB Navi2 (PDB: 4FEA)

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Ligands
Code	Name		Style	Show	Link
0TE	Chloro{methyl hydrogenato(3-)-kappa~2~N,S [pyridin-2-yl(pyridin-2(1h)-ylidene-kappan)methyl]carbonodithiohydrazonate}copper				PoSSuM

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Download interaction data: 4FEA

Code :

4FEA PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of CASPASE-7 in Complex with allosteric inhibitor

Release Data :

2012-08-01

Compound :

mol_id	molecule	chains	synonym
1	Caspase-7	A,B	CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3
	ec: 3.4.22.60 fragment: P20/P10 catalytic domain (UNP residues 57-303)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CASP7, MCH3

Authors :

Kabaleeswaran, V.

Keywords :

cysteine protease, apoptosis, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 3.7900 Å )

Citation :

A class of allosteric caspase inhibitors identified by high-throughput screening.

Feldman, T.,Kabaleeswaran, V.,Jang, S.B. et al.
(2012) Mol.Cell 47 : 585 - 595

Chain :

A, B

UniProt :

P55210 (CASP7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-\|-.	3.4.22.60	PubMed:10497198, PubMed:11257230, PubMed:11701129, PubMed:12824163, PubMed:16123041, PubMed:16374543, PubMed:16916640, PubMed:17646170, PubMed:17697120, PubMed:18723680, PubMed:19581639, PubMed:19617626, PubMed:20566630, PubMed:22451931, PubMed:23650375, PubMed:23897474, PubMed:27032039, PubMed:31586028, PubMed:34156061
	-

PDB ID: 4FEA