PDB ID: 4FCR
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Structure summary
Code : | 4FCR PDBj RCSB PDB PDBe | ||||||||||||
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Header : | CHAPERONE/CHAPERONE INHIBITOR | ||||||||||||
Title : | Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-D]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization | ||||||||||||
Release Data : | 2012-10-24 | ||||||||||||
Compound : |
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Source : |
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Authors : | Davies, N.G., Browne, H., Davis, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M.J., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P. | ||||||||||||
Keywords : | Heat Shock Protein, Hsp90, ATPase, Fragments, Structure-based design, CHAPERONE-CHAPERONE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.698 Å ) | ||||||||||||
Citation : |
Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Davies, N.G.,Browne, H.,Davis, B.
et al.
PubMed: 23018093 |
Reaction
Chain : | A | ||||||||
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UniProt : | P07900 (HS90A_HUMAN) | ||||||||
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