Brand  (β version)

PDB ID: 4FC6

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Ligands
Code Name Style Show Link
HXC Hexanoyl-coenzyme a PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4FC6   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR
Release Data : 2012-07-04
Compound :
mol_id molecule chains synonym
1 Peroxisomal 2,4-dienoyl-CoA reductase A,B,C,D pDCR, 2,4-dienoyl-CoA reductase 2
ec: 1.3.1.34
fragment: UNP residues 2-278
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DECR2, PDCR
Authors : Hua, T., Wu, D., Wang, J., Shaw, N., Liu, Z.-J.
Keywords : SDR/Rossmann fold, peroxisomal beta-oxidation, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids

Hua, T.,Wu, D.,Ding, W.  et al.
(2012)  J.Biol.Chem.  287 : 28956 - 28965

PubMed: 22745130
DOI: 10.1074/jbc.M112.385351

Reaction

Chain : A, B, C, D
UniProt : Q9NUI1 (DECR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+) 1.3.1.124 PubMed:11514237, PubMed:22745130
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a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)- enoyl-CoA + NADP(+) 1.3.1.124 PubMed:11514237, PubMed:22745130
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(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) - PubMed:11514237
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