PDB ID: 4FA3
Hetero Atom Contents
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Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
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0SL | (3r)-1-(naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid | PoSSuM | |||
ACT | Acetate ion | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM | |||
NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
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Download interaction data: 4FA3
Structure summary
Code : | 4FA3 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor | ||||||||||||
Title : | Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (R)-1-(naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid (86) | ||||||||||||
Release Data : | 2012-10-10 | ||||||||||||
Compound : |
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Source : |
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Authors : | Turnbull, A.P., Jamieson, S.M.F., Brooke, D.G., Heinrich, D., Atwell, G.J., Silva, S., Hamilton, E.J., Rigoreau, L.J.M., Trivier, E., Soudy, C., Samlal, S.S., Owen, P.J., Schroeder, E., Raynham, T., Flanagan, J.U., Denny, W.A. | ||||||||||||
Keywords : | TIM-barrel, aldo-keto reductase, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.20 Å ) | ||||||||||||
Citation : |
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3
Jamieson, S.M.,Brooke, D.G.,Heinrich, D.
et al.
PubMed: 22877157 |
Reaction
Chain : | A | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | P42330 (AK1C3_HUMAN) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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