Brand  (β version)

PDB ID: 4F9O

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Ligands
Code Name Style Show Link
NA Sodium ion PoSSuM
BGC Beta-D-glucopyranose PoSSuM
0NZ 2-deoxy-6-O-phosphono-beta-D-glucopyranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4F9O   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate
Release Data : 2013-06-12
Compound :
mol_id molecule chains synonym
1 Hexokinase-1 A,B Brain form hexokinase, Hexokinase type I, HK I
ec: 2.7.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HK1
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET24
Authors : Shen, L., Honzatko, R.B.
Keywords : hexokinase, 2-deoxy Glucose-6-Phosphate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.6500 Å )
Citation :

Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I

Shen, L.,Gao, Y.,Honzatko, R.B.
to be published 

Reaction

Chain : A, B
UniProt : P19367 (HXK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+) 2.7.1.1 PubMed:1637300, PubMed:27374331
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ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+) 2.7.1.1 UniProtKB:P05708
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ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) 2.7.1.1 UniProtKB:P05708
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ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+) 2.7.1.1 UniProtKB:P05708
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ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+) 2.7.1.1 PubMed:27374331
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