Het-PDB Navi2 (PDB: 4F9M)

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Ligands
Code	Name		Style	Show	Link
FCM	(9as)-8-acetyl-N-[(2-ethyl-4-fluoronaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[B,D]furan-4-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Modification
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Download interaction data: 4F9M

Code :

4F9M PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION/TRANSCRIPTION REGULATOR

Title :

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

Release Data :

2012-08-08

Compound :

mol_id	molecule	chains	synonym
1	Peroxisome proliferator-activated receptor gamma	A	PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
	fragment: Ligand binding domain, UNP residues 234-505

mol_id	molecule	chains	synonym
2	peptide from Nuclear receptor coactivator 1	C	NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
	fragment: LXXLL box, UNP residues 686-700

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PPARG, NR1C3 expression_system_vector_type: plasmid

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes other_details: This sequence occurs naturally in humans.

Authors :

Matsui, Y., Hanzawa, H.

Keywords :

three-layered alpha-helical sandwich, transcription regulation, TRANSCRIPTION-TRANSCRIPTION REGULATOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators

Furukawa, A.,Arita, T.,Fukuzaki, T. et al.
(2012) Eur.J.Med.Chem. 54 : 522 - 533

Chain :

UniProt :

Q15788 (NCOA1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)	2.3.1.48	-
	-	-

PDB ID: 4F9M