Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
FCM (9as)-8-acetyl-N-[(2-ethyl-4-fluoronaphthalen-1-yl)methyl]-1,7-dihydroxy-3-methoxy-9a-methyl-9-oxo-9,9a-dihydrodibenzo[B,D]furan-4-carboxamide
Code : 4F9M
Header : TRANSCRIPTION/TRANSCRIPTION REGULATOR
Title : Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator
Release Data : 2012-08-08
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator-activated receptor gamma A PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
fragment: Ligand binding domain, UNP residues 234-505
mol_id molecule chains synonym
2 peptide from Nuclear receptor coactivator 1 C NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
fragment: LXXLL box, UNP residues 686-700
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PPARG, NR1C3
expression_system_vector_type: plasmid
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
other_details: This sequence occurs naturally in humans.
Authors : Matsui, Y., Hanzawa, H.
Keywords : three-layered alpha-helical sandwich, transcription regulation, TRANSCRIPTION-TRANSCRIPTION REGULATOR complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARg modulators

Furukawa, A.,Arita, T.,Fukuzaki, T.  et al.
(2012)  Eur.J.Med.Chem.  54 : 522 - 533

PubMed: 22727448
DOI: 10.1016/j.ejmech.2012.05.040

Chain : A
UniProt : P37231 (PPARG_HUMAN)
Reaction : -
Chain : C
UniProt : Q15788 (NCOA1_HUMAN)
Reaction : Acetyl-CoA + [histone] = CoA + acetyl- [histone].