Brand  (β version)

PDB ID: 4F6U

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Ligands
Code Name Style Show Link
0SR 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea PoSSuM
DMS Dimethyl sulfoxide PoSSuM
EDO 1,2-ethanediol PoSSuM
FMT Formic acid PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4F6U   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSCRIPTION/INHIBITOR
Title : Crystal structure of human CDK8/CYCC in complex with compound 5 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]urea)
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 8 A Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35
ec: 2.7.11.22, 2.7.11.23
fragment: UNP residues 1-403
mol_id molecule chains synonym
2 Cyclin-C B SRB11 homolog, hSRB11
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK8
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CCNC
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Schneider, E.V., Boettcher, J., Huber, R., Maskos, K.
Keywords : protein kinase complex, Proteros, TRANSFERASE-TRANSCRIPTION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structure-kinetic relationship study of CDK8/CycC specific compounds.

Schneider, E.V.,Bottcher, J.,Huber, R.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 8081 - 8086

PubMed: 23630251
DOI: 10.1073/pnas.1305378110

Reaction

Chain : A
UniProt : P49336 (CDK8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.22 PubMed:10993082
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.22 PubMed:10993082
-
[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+) 2.7.11.23 PubMed:10993082
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000250
-
Chain : B
UniProt : P24863 (CCNC_HUMAN)
Reaction : -