Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0S7 5-bromo-N~4~-(3-methyl-1h-pyrazol-5-yl)-N~2~-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine
EDO 1,2-ethanediol
Code : 4F63
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of Human Fibroblast Growth Factor Receptor 1 Kinase domain in complex with compound 1
Release Data : 2012-06-06
Compound :
mol_id molecule chains synonym
1 Fibroblast growth factor receptor 1 A,B FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr
ec: 2.7.10.1
fragment: kinase domain (UNP residues 458-765)
mutation: C488A, C584S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
expression_system_strain: BL21(DE3)
Authors : Norman, R.A., Breed, J., Ogg, D.
Keywords : kinase, ATP binding, phosphorylation, trans-membrane, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.55 Å )
Citation :

Protein-Ligand Crystal Structures Can Guide the Design of Selective Inhibitors of the FGFR Tyrosine Kinase.

Norman, R.A.,Schott, A.K.,Andrews, D.M.  et al.
(2012)  J.Med.Chem.  55 : 5003 - 5012

PubMed: 22612866
DOI: 10.1021/jm3004043

Chain : A, B
UniProt : P11362 (FGFR1_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.