Brand  (β version)

PDB ID: 4F4P

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0SB N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4F4P   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : SYK in COMPLEX WITH LIGAND LASW836
Release Data : 2012-12-12
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase SYK A Spleen tyrosine kinase, p72-Syk
ec: 2.7.10.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SYK
Authors : Lopez, M., Segarra, V., Vidal, B., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M., Nagel, S., Schreiner, P.
Keywords : Tyrosine-protein kinase, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3700 Å )
Citation :

Highly potent aminopyridines as Syk kinase inhibitors.

Castillo, M.,Forns, P.,Erra, M.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 5419 - 5423

PubMed: 22877633
DOI: 10.1016/j.bmcl.2012.07.045

Reaction

Chain : A
UniProt : P43405 (KSYK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
-