Brand  (β version)

PDB ID: 4EZ5

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Ligands
Code Name Style Show Link
0RS {5-[4-(dimethylamino)piperidin-1-yl]-1h-imidazo[4,5-B]pyridin-2-yl}[2-(isoquinolin-4-yl)pyridin-4-yl]methanone PoSSuM
Non-standard Residues
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Structure summary

Code : 4EZ5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : CDK6 (monomeric) in complex with inhibitor
Release Data : 2013-02-06
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 6 A Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE
ec: 2.7.11.22
fragment: UNP residues 1-301
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDK6, CDKN6
Authors : Chopra, R., Xu, M.
Keywords : Protein Kinase, ATP Binding, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.7000 Å )
Citation :

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.

Cho, Y.S.,Angove, H.,Brain, C.  et al.
(2012)  ACS Med Chem Lett  3 : 445 - 449

PubMed: 24900493
DOI: 10.1021/ml200241a

Reaction

Chain : A
UniProt : Q00534 (CDK6_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 -
-