Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
ZN Zinc ion
0RV (2s)-2-[(1s,2r)-1-carboxy-2-hydroxypropyl]-4-{[(3s,5s)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-2h-pyrrole-5-carboxylic acid
Code : 4EYL
Header : Hydrolase/antibiotic
Title : Crystal structure of NDM-1 bound to hydrolyzed meropenem
Release Data : 2012-08-08
Compound :
mol_id molecule chains synonym
1 Beta-lactamase NDM-1 A,B NDM-1, Metallo-beta-lactamase NDM-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:562)
gene: blaNDM-1
Authors : Strynadka, N.C.J., King, D.T.
Keywords : Metallo-Beta-Lactamase, antibiotic, Hydrolase-antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

New Delhi Metallo-Beta-Lactamase: Structural Insights into Beta-Lactam Recognition and Inhibition

King, D.T.,Worrall, L.J.,Gruninger, R.  et al.
(2012)  J.Am.Chem.Soc.  134 : 11362 - 11365

PubMed: 22713171
DOI: 10.1021/ja303579d

Chain : A, B
UniProt : C7C422 (BLAN1_KLEPN)
Reaction : A beta-lactam + H(2)O = a substituted beta- amino acid.