PDB ID: 4EWO
Hetero Atom Contents
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996 | N-[(2s,3r)-4-{[(4s)-2-(2,2-dimethylpropyl)-6,6-dimethyl-4,5,6,7-tetrahydro-2h-indazol-4-yl]amino}-3-hydroxy-1-phenylbutan-2-yl]acetamide | PoSSuM |
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Download interaction data: 4EWO
Structure summary
Code : | 4EWO PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Design and synthesis of potent hydroxyethylamine (hea) bace-1 inhibitors | ||||||||||||
Release Data : | 2012-10-31 | ||||||||||||
Compound : |
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Authors : | Borkakoti, N., Lindberg, J., Derbyshire, D. | ||||||||||||
Keywords : | BACE, BETA-SECRETASE, STATINE, INHIBITOR, ASPARTYL PROTEASE, GLYCOPROTEIN, MEMBRANE, PROTEASE, TRANSMEMBRANE, ZYMOGEN, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.8000 Å ) | ||||||||||||
Citation : |
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates.
Sund, C.,Belda, O.,Borkakoti, N.
et al.
PubMed: 23010268 |
Reaction
Chain : | A | ||||||||
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UniProt : | P56817 (BACE1_HUMAN) | ||||||||
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