Brand  (β version)

PDB ID: 4EUC

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Ligands
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0RQ [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3r)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-(4-oxidanylidenepentylamino)propyl]amino]butyl] hydrogen phosphate PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4EUC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Succinyl-CoA:acetate CoA-transferase (AarCH6-E294A) in complex with dethiaacetyl-CoA
Release Data : 2012-10-10
Compound :
mol_id molecule chains
1 Succinyl-CoA:acetate coenzyme A transferase A,B
ec: 2.8.3.18
mutation: E294A
Source :
mol_id organism_scientific expression_system
1 Acetobacter aceti  (taxid:435) Escherichia coli  (taxid:562)
strain: 1023
gene: aarC
expression_system_strain: C41(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET23a
Authors : Mullins, E.A., Kappock, T.J.
Keywords : TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.6440 Å )
Citation :

Crystal Structures of Acetobacter aceti Succinyl-Coenzyme A (CoA):Acetate CoA-Transferase Reveal Specificity Determinants and Illustrate the Mechanism Used by Class I CoA-Transferases.

Mullins, E.A.,Kappock, T.J.
(2012)  Biochemistry  51 : 8422 - 8434

PubMed: 23030530
DOI: 10.1021/bi300957f

A specialized citric acid cycle requiring succinyl-coenzyme A (CoA):acetate CoA-transferase (AarC) confers acetic acid resistance on the acidophile Acetobacter aceti

Mullins, E.A.,Francois, J.A.,Kappock, T.J.
(2008)  J.Bacteriol.  190 : 4933 - 4940

PubMed: 18502856

Reaction

Chain : A, B
UniProt : B3EY95 (SCACT_ACEAC)
Reaction: EC: Evidence:
Physiological Direction:
acetate + succinyl-CoA = acetyl-CoA + succinate 2.8.3.18 PubMed:18502856, PubMed:23030530, Ref.3
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