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Ligands
Code Name Style Show Link
NA Sodium ion
Non-standard Residues
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Glycosylation
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Code : 4ET0   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of circularly permuted human asparaginase-like protein 1
Release Data : 2012-09-26
Compound :
mol_id molecule chains synonym
1 L-asparaginase A,B Asparaginase-like protein 1, L-asparagine amidohydrolase
ec: 3.5.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ASRGL1, ALP, CRASH
Authors : Li, W.Z., Yogesha, S.D., Zhang, Y.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 3.30 Å )
Citation :

Uncoupling Intramolecular Processing and Substrate Hydrolysis in the N-Terminal Nucleophile Hydrolase hASRGL1 by Circular Permutation.

Li, W.,Cantor, J.R.,Yogesha, S.D.  et al.
(2012)  Acs Chem.Biol.  7 : 1840 - 1847

PubMed: 22891768
DOI: 10.1021/cb300232n

Chain : A, B
UniProt : Q7L266 (ASGL1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + L-asparagine = L-aspartate + NH4(+) 3.5.1.1 PubMed:19839645, PubMed:22891768, PubMed:27106100
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Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide. 3.4.19.5 PubMed:19839645
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