Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
MG Magnesium ion
0QY N-[2-(1h-indol-3-ylmethyl)-1h-benzimidazol-5-yl]-L-prolinamide
GDP Guanosine-5'-diphosphate
Code : 4EPY
Header : HYDROLASE
Title : Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation
Release Data : 2012-05-23
Compound :
mol_id molecule chains synonym
1 GTPase KRas A K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, GTPase KRas, N-terminally processed
ec: 3.6.5.2
mutation: G12V, C118S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KRAS, KRAS2, RASK2
Authors : Sun, Q., Burke, J.P., Phan, J., Burns, M.C., Olejniczak, E.T., Waterson, A.G., Lee, T., Rossanese, O.W., Fesik, S.W.
Keywords : Small molecule complex crystal structure, KRas, p21, GTP-binding protein, oncogenes, binder, HYDROLASE, Inhibitor of Sos-mediated activation
Exp. method : X-RAY DIFFRACTION ( 1.801 Å )
Citation :

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.

Sun, Q.,Burke, J.P.,Phan, J.  et al.
(2012)  Angew.Chem.Int.Ed.Engl.  51 : 6140 - 6143

PubMed: 22566140
DOI: 10.1002/anie.201201358

Chain : A
UniProt : P01116 (RASK_HUMAN)
Reaction : -