Brand  (β version)

PDB ID: 4ENY

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Ligands
Code Name Style Show Link
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
J19 (2z,5z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-methoxybenzylidene)-1,3-thiazolidin-4-one PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4ENY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : Crystal Structure of Pim-1 kinase in complex with (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-methoxybenzylidene)thiazolidin-4-one
Release Data : 2012-08-08
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase pim-1 A
ec: 2.7.11.1
fragment: Protein kinase domain, UNP RESIDUES 120-404
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cell-free protein synthesis
gene: PIM1
expression_system_vector_type: Plasmid
expression_system_plasmid: pCR2.1-TOPO
Authors : Parker, L.J., Handa, N., Yokoyama, S.
Keywords : Pim-1 kinase, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.8010 Å )
Citation :

Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor

Parker, L.J.,Watanabe, H.,Tsuganezawa, K.  et al.
(2012)  Acta Crystallogr.,Sect.F  68 : 860 - 866

PubMed: 22869110
DOI: 10.1107/S1744309112027108

Reaction

Chain : A
UniProt : P11309 (PIM1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862
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