Het-PDB Navi2 (PDB: 4EM7)

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Ligands
Code	Name		Style	Show	Link
0RA	3-[3-(1h-pyrrolo[2,3-B]pyridin-5-yl)phenyl]propanoic acid				PoSSuM

Non-standard Residues
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Download interaction data: 4EM7

Code :

4EM7 PDBj RCSB PDB PDBe

Header :

ISOMERASE/ISOMERASE INHIBITOR

Title :

Crystal structure of a topoisomerase ATP inhibitor

Release Data :

2012-08-01

Compound :

mol_id	molecule	chains
1	DNA topoisomerase IV, B subunit	A
	ec: 5.99.1.- fragment: ATPase domain (UNP Residues 1-226)

Source :

mol_id	organism_scientific	expression_system
1	Streptococcus pneumoniae GA47373 (taxid:760835)	Escherichia coli (taxid:562)
	gene: ParE, SPAR94_0831 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid

Authors :

Boriack-Sjodin, P.A., Manchester, J.

Keywords :

protein-inhibitor complex, ATP binding, structure-based drug design, antimicrobial, virtual screen, ISOMERASE-ISOMERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.9000 Å )

Citation :

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.

Manchester, J.I.,Dussault, D.D.,Rose, J.A. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 5150 - 5156

PDB ID: 4EM7