Brand  (β version)

PDB ID: 4ELU

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Ligands
Code Name Style Show Link
0R6 2'-deoxy-5-[(4-ethynylphenyl)ethynyl]cytidine 5'-(tetrahydrogen triphosphate) PoSSuM
ACT Acetate ion PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
PGE Triethylene glycol PoSSuM
Non-standard Residues
Code Name Show
DDG 2',3'-dideoxy-guanosine-5'-monophosphate
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4ELU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : Snapshot of the large fragment of DNA polymerase I from Thermus Aquaticus processing modified pyrimidines
Release Data : 2013-03-27
Compound :
mol_id molecule chains synonym
1 DNA polymerase I, thermostable A Taq polymerase 1
ec: 2.7.7.7
fragment: UNP RESIDUES 293-832
mol_id molecule chains
2 DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DDG))-3') B
other_details: DNA primer
mol_id molecule chains
3 DNA (5'-D(*AP*AP*AP*GP*CP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3') C
other_details: DNA template
Source :
mol_id organism_scientific expression_system
1 Thermus aquaticus  (taxid:271) Escherichia coli  (taxid:562)
gene: polA, pol1
mol_id organism_scientific
2 Synthetic DNA  (taxid:32630)
synthetic: yes
mol_id organism_scientific
3 Synthetic DNA  (taxid:32630)
synthetic: yes
Authors : Marx, A., Diederichs, K., Obeid, S.
Keywords : DNA polymerase, modified nucleotides, A family, DNA synthesis, rigid linker, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.800 Å )
Citation :

Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site.

Obeid, S.,Busskamp, H.,Welte, W.  et al.
(2012)  Chem.Commun.(Camb.)  48 : 8320 - 8322

PubMed: 22766607
DOI: 10.1039/c2cc34181f

Reaction

Chain : A
UniProt : P19821 (DPO1_THEAQ)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 -
-