Brand  (β version)

PDB ID: 4EKL

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Ligands
Code Name Style Show Link
0RF (2s)-2-(4-chlorophenyl)-1-{4-[(5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta[D]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Structure summary

Code : 4EKL   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Akt1 with GDC0068
Release Data : 2012-05-23
Compound :
mol_id molecule chains synonym
1 RAC-alpha serine/threonine-protein kinase A Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha
ec: 2.7.11.1
fragment: UNP residues 144-480
mutation: S473D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: AKT1, PKB, RAC
Authors : Wu, W.-I., Vigers, G.P.A., Morales, T.H., Brandhuber, B.J.
Keywords : Phosphotransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt.

Lin, K.,Lin, J.,Wu, W.I.  et al.
(2012)  Sci.Signal.  5 : ra37 - ra37

PubMed: 22569334
DOI: 10.1126/scisignal.2002618

Reaction

Chain : A
UniProt : P31749 (AKT1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12172553, PubMed:15861136, PubMed:16139227, PubMed:1718748, PubMed:1851997, PubMed:26440888, PubMed:31548394, PubMed:32322062, PubMed:33594058
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12172553, PubMed:16139227, PubMed:1718748, PubMed:1851997
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