Brand  (β version)

PDB ID: 4EK5

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Ligands
Code Name Style Show Link
03K N-(5-cyclopropyl-1h-pyrazol-3-yl)benzene-1,4-dicarboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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ACE Acetyl group

Structure summary

Code : 4EK5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A Cell division protein kinase 2, p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human TRICHOPLUSIA NI  (taxid:7111)
gene: CDK2, CDKN2
expression_system_cell_line: HIGH-FIVE
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PFB1
Authors : Kang, Y.N., Stuckey, J.A.
Keywords : ALPHA AND BETA PROTEIN (A+B), TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Kang, Y.N.,Stuckey, J.A.
To be Published 

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.22 PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:21565702
Binds 2 Mg(2+) ions.