PDB ID: 4EJN
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
---|---|---|---|---|---|
0R4 | N-(4-{5-[3-(acetylamino)phenyl]-2-(2-aminopyridin-3-yl)-3h-imidazo[4,5-B]pyridin-3-yl}benzyl)-3-fluorobenzamide | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM | |||
SBT | 2-butanol | PoSSuM |
Code | Name | Show |
---|
Code | Name | Emphasize |
---|
Code | Name | Show |
---|
Download interaction data: 4EJN
Structure summary
Code : | 4EJN PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-B]pyridin-3-yl)benzyl)-3-fluorobenzamide | ||||||||||||
Release Data : | 2012-05-23 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Eathiraj, S. | ||||||||||||
Keywords : | Akt1, autoinhibition, allosteric inhibitor, kinase inhibitor, hydrophobic collapase, Kinase, ATPase, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.19 Å ) | ||||||||||||
Citation : |
Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
Ashwell, M.A.,Lapierre, J.M.,Brassard, C.
et al.
PubMed: 22533986 |
Reaction
Chain : | A | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProt : | P31749 (AKT1_HUMAN) | ||||||||||||
|