Brand  (β version)

PDB ID: 4EJI

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
0QA 4-[methyl(nitroso)amino]-1-(pyridin-3-yl)butan-1-one PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4EJI   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Human Cytochrome P450 2A13 in complex with two molecules of 4-(methylnitrosamino)-1-(3-puridyl)-1-butanone
Release Data : 2012-06-06
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 2A13 A CYPIIA13
ec: 1.14.14.1
fragment: unp residues 31-494
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CYP2A13
expression_system_strain: TOPP3
expression_system_vector_type: plasmid
expression_system_plasmid: pKK2A13dH
Authors : DeVore, N.M., Scott, E.E.
Keywords : CYP2A13, cytochrome P450 2A13, P450 2A13, heme protein, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes.

DeVore, N.M.,Scott, E.E.
(2012)  J.Biol.Chem.  287 : 26576 - 26585

PubMed: 22700965
DOI: 10.1074/jbc.M112.372813

Reaction

Chain : A
UniProt : Q16696 (CP2AD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] 1.14.14.1 -
-